| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LPCAT2 |
| Gene ID: | 54947 |
| Uniprot ID: | PCAT2_HUMAN |
| Immunogen Region: | 160-544 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-544 of human LPCAT2 (NP_060309.2). |
| Immunogen Sequence: | LPSMVSRNENAQVPLIGRLL RAVQPVLVSRVDPDSRKNTI NEIIKRTTSGGEWPQILVFP EGTCTNRSCLITFKPGAFIP GVPVQPVLLRYPNKLDTVTW TWQGYTFIQLCMLTFCQLFT KVEVEFMPVQVPNDEEKNDP VLFANKVRNLMAEALGIPVT DHTYEDCRLMISAGQLTLPM EAGLVEFTKISRKLKLDWDG VRKHLDEYASIASSSKGGRI GIEEFAKYLKLPVSDVLRQ |
| Function | Exhibits both acyltransferase and acetyltransferase activities. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Involved in the regulation of lipid droplet number and size. |
| Protein Name | Lysophosphatidylcholine Acyltransferase 2 Lpc Acyltransferase 2 Lpcat-2 Lysopc Acyltransferase 2 1-Acylglycerol-3-Phosphate O-Acyltransferase 11 1-Agp Acyltransferase 11 1-Agpat 11 1-Acylglycerophosphocholine O-Acyltransferase 1-Alkenylglycerophosphocholine O-Acyltransferase 1-Alkylglycerophosphocholine O-Acetyltransferase Acetyl-Coa -Lyso-Platelet-Activating Factor Acetyltransferase Acetyl-Coa -Lyso-Paf Acetyltransferase Lyso-Paf Acetyltransferase Lysopafat Acyltransferase-Like 1 Lysophosphatidic Acid Acyltransferase Alpha Lpaat-Alpha |
| Database Links | Reactome: R-HSA-1482788 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Golgi Apparatus Membrane Cell Membrane Lipid Droplet |
| Alternative Antibody Names | Anti-Lysophosphatidylcholine Acyltransferase 2 antibody Anti-Lpc Acyltransferase 2 antibody Anti-Lpcat-2 antibody Anti-Lysopc Acyltransferase 2 antibody Anti-1-Acylglycerol-3-Phosphate O-Acyltransferase 11 antibody Anti-1-Agp Acyltransferase 11 antibody Anti-1-Agpat 11 antibody Anti-1-Acylglycerophosphocholine O-Acyltransferase antibody Anti-1-Alkenylglycerophosphocholine O-Acyltransferase antibody Anti-1-Alkylglycerophosphocholine O-Acetyltransferase antibody Anti-Acetyl-Coa -Lyso-Platelet-Activating Factor Acetyltransferase antibody Anti-Acetyl-Coa -Lyso-Paf Acetyltransferase antibody Anti-Lyso-Paf Acetyltransferase antibody Anti-Lysopafat antibody Anti-Acyltransferase-Like 1 antibody Anti-Lysophosphatidic Acid Acyltransferase Alpha antibody Anti-Lpaat-Alpha antibody Anti-LPCAT2 antibody Anti-AGPAT11 antibody Anti-AYTL1 antibody |
Information sourced from Uniprot.org