| Short Description : | Rabbit polyclonal LNX1 (501-728) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LNX1 |
| Gene ID: | 84708 |
| Uniprot ID: | LNX1_HUMAN |
| Immunogen Region: | 501-728 |
| Immunogen Sequence: | ITCHEKVVNIQKDPGESLGM TVAGGASHREWDLPIYVISV EPGGVISRDGRIKTGDILLN VDGVELTEVSRSEAVALLKR TSSSIVLKALEVKE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 501-594 of human LNX1 (NP_001119800.1). |
| Tissue Specificity | Expressed in heart, placenta, kidney, pancreas and brain. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. |
| Protein Name | E3 Ubiquitin-Protein Ligase LnxLigand Of Numb-Protein X 1Numb-Binding Protein 1Pdz Domain-Containing Ring Finger Protein 2Ring-Type E3 Ubiquitin Transferase Lnx |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lnx antibodyAnti-Ligand Of Numb-Protein X 1 antibodyAnti-Numb-Binding Protein 1 antibodyAnti-Pdz Domain-Containing Ring Finger Protein 2 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Lnx antibodyAnti-LNX1 antibodyAnti-LNX antibodyAnti-PDZRN2 antibodyAnti-UNQ574 antibodyAnti-PRO1136 antibody |
Information sourced from Uniprot.org
