| Tissue Specificity | Expressed in heart, placenta, kidney, pancreas and brain. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. |
| Protein Name | E3 Ubiquitin-Protein Ligase LnxLigand Of Numb-Protein X 1Numb-Binding Protein 1Pdz Domain-Containing Ring Finger Protein 2Ring-Type E3 Ubiquitin Transferase Lnx |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lnx antibodyAnti-Ligand Of Numb-Protein X 1 antibodyAnti-Numb-Binding Protein 1 antibodyAnti-Pdz Domain-Containing Ring Finger Protein 2 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Lnx antibodyAnti-LNX1 antibodyAnti-LNX antibodyAnti-PDZRN2 antibodyAnti-UNQ574 antibodyAnti-PRO1136 antibody |
Information sourced from Uniprot.org
