| Short Description : | Rabbit polyclonal LIPA (110-399) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LIPA |
| Gene ID: | 3988 |
| Uniprot ID: | LICH_HUMAN |
| Immunogen Region: | 110-399 |
| Immunogen Sequence: | DAGFDVWMGNSRGNTWSRKH KTLSVSQDEFWAFSYDEMAK YDLPASINFILNKTGQEQVY YVGHSQGTTIGFIAFSQIPE LAKRIKMFFALGPVASVAFC TSPMAKLGRLPDHLIKDLFG DKEFLPQSAFLKWLGTHVCT HVILKELCGNLCFLLCGFNE RNLNMSRVDVYTTHSPAGTS VQNMLHWSQAVKFQKFQAFD WGSSAKNYFHYNQSYPPTYN VKDMLVPTAVWSGGHDWLA |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-399 of human LIPA (NP_001121077.1). |
| Tissue Specificity | Most abundantly expressed in brain, lung, kidney and mammary gland, a moderate expression seen in placenta and expressed at low levels in the liver and heart. |
| Post Translational Modifications | Glycosylation is not essential for catalytic activity. |
| Function | Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions. |
| Protein Name | Lysosomal Acid Lipase/Cholesteryl Ester HydrolaseAcid Cholesteryl Ester HydrolaseLalCholesteryl EsteraseDiacylglycerol LipaseLipase ASterol EsteraseTriacylglycerol Ester HydrolaseTriacylglycerol Lipase |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase antibodyAnti-Acid Cholesteryl Ester Hydrolase antibodyAnti-Lal antibodyAnti-Cholesteryl Esterase antibodyAnti-Diacylglycerol Lipase antibodyAnti-Lipase A antibodyAnti-Sterol Esterase antibodyAnti-Triacylglycerol Ester Hydrolase antibodyAnti-Triacylglycerol Lipase antibodyAnti-LIPA antibody |
Information sourced from Uniprot.org
