Anti-LILRA4 antibody (391-440 aa) (STJ96623)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human LILRA4 at the amino acid range 391-440
General Information
| Short Description | Rabbit polyclonal anti-Leukocyte immunoglobulin-like receptor subfamily A member 4 (391-440 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LILRA4 |
| Gene ID | 23547 |
| Uniprot ID | LIRA4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human LILRA4 at the amino acid range 391-440 |
| Immunogen Region | 391-440 aa |
| Specificity | CD85g Polyclonal Antibody detects endogenous levels of CD85g protein. |
Additional Info
| Function | Functions coreceptor to limit the innate immune responses to viral infections.signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4Cd85 Antigen-Like Family Member GImmunoglobulin-Like Transcript 7Ilt-7Cd Antigen Cd85g |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 antibodyAnti-Cd85 Antigen-Like Family Member G antibodyAnti-Immunoglobulin-Like Transcript 7 antibodyAnti-Ilt-7 antibodyAnti-Cd Antigen Cd85g antibodyAnti-LILRA4 antibodyAnti-ILT7 antibody |
Information sourced from Uniprot.org