| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LGR6 (350-510) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LGR6 |
| Gene ID: |
59352 |
| Uniprot ID: |
LGR6_HUMAN |
| Immunogen Region: |
350-510 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-510 of human LGR6 (NP_001017403.1). |
| Immunogen Sequence: |
QLPRLRVLELSHNQIEELPS LHRCQKLEEIGLQHNRIWEI GADTFSQLSSLQALDLSWNA IRSIHPEAFSTLHSLVKLDL TDNQLTTLPLAGLGGLMHLK LKGNLALSQAFSKDSFPKLR ILEVPYAYQCCPYGMCASFF KASGQWEAEDLHLDDEESSK R |
| Function | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. |
| Protein Name | Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 |
| Database Links | Reactome: R-HSA-4641263 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 antibodyAnti-LGR6 antibodyAnti-UNQ6427 antibodyAnti-PRO21331 antibodyAnti-VTS20631 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
