| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe (121-170 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LFNG |
| Gene ID: |
3955 |
| Uniprot ID: |
LFNG_HUMAN |
| Immunogen Region: |
121-170 aa |
| Specificity: |
Lunatic Fringe Polyclonal Antibody detects endogenous levels of Lunatic Fringe protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human LFNG at the amino acid range 121-170 |
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. |
| Protein Name | Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic FringeO-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-5083630Reactome: R-HSA-9824272 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic Fringe antibodyAnti-O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase antibodyAnti-LFNG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
