| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LAMC2 |
| Gene ID: | 3918 |
| Uniprot ID: | LAMC2_HUMAN |
| Immunogen Region: | 746-860 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 746-860 of human LAMC2 (NP_005553.2). |
| Immunogen Sequence: | DHYVGPNGFKSLAQEATRLA ESHVESASNMEQLTRETEDY SKQALSLVRKALHEGVGSGS GSPDGAVVQGLVEKLEKTKS LAQQLTREATQAEIEADRSY QHSLRLLDSVSRLQG |
| Tissue Specificity | The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli. |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate (CS). CS attachment is on either Ser-803 or Ser-805. |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. |
| Protein Name | Laminin Subunit Gamma-2 Cell-Scattering Factor 140 Kda Subunit Csf 140 Kda Subunit Epiligrin Subunit Gamma Kalinin Subunit Gamma Kalinin/Nicein/Epiligrin 100 Kda Subunit Ladsin 140 Kda Subunit Laminin B2t Chain Laminin-5 Subunit Gamma Large Adhesive Scatter Factor 140 Kda Subunit Nicein Subunit Gamma |
| Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-2022090 Reactome: R-HSA-2214320 Reactome: R-HSA-3000157 Reactome: R-HSA-3000171 Reactome: R-HSA-446107 Reactome: R-HSA-8874081 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix Basement Membrane Major Component |
| Alternative Antibody Names | Anti-Laminin Subunit Gamma-2 antibody Anti-Cell-Scattering Factor 140 Kda Subunit antibody Anti-Csf 140 Kda Subunit antibody Anti-Epiligrin Subunit Gamma antibody Anti-Kalinin Subunit Gamma antibody Anti-Kalinin/Nicein/Epiligrin 100 Kda Subunit antibody Anti-Ladsin 140 Kda Subunit antibody Anti-Laminin B2t Chain antibody Anti-Laminin-5 Subunit Gamma antibody Anti-Large Adhesive Scatter Factor 140 Kda Subunit antibody Anti-Nicein Subunit Gamma antibody Anti-LAMC2 antibody Anti-LAMB2T antibody Anti-LAMNB2 antibody |
Information sourced from Uniprot.org