| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LAMC2 (746-860) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LAMC2 |
| Gene ID: |
3918 |
| Uniprot ID: |
LAMC2_HUMAN |
| Immunogen Region: |
746-860 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 746-860 of human LAMC2 (NP_005553.2). |
| Immunogen Sequence: |
DHYVGPNGFKSLAQEATRLA ESHVESASNMEQLTRETEDY SKQALSLVRKALHEGVGSGS GSPDGAVVQGLVEKLEKTKS LAQQLTREATQAEIEADRSY QHSLRLLDSVSRLQG |
| Tissue Specificity | The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli. |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate (CS). CS attachment is on either Ser-803 or Ser-805. |
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. |
| Protein Name | Laminin Subunit Gamma-2Cell-Scattering Factor 140 Kda SubunitCsf 140 Kda SubunitEpiligrin Subunit GammaKalinin Subunit GammaKalinin/Nicein/Epiligrin 100 Kda SubunitLadsin 140 Kda SubunitLaminin B2t ChainLaminin-5 Subunit GammaLarge Adhesive Scatter Factor 140 Kda SubunitNicein Subunit Gamma |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022090Reactome: R-HSA-2214320Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-446107Reactome: R-HSA-8874081 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMajor Component |
| Alternative Antibody Names | Anti-Laminin Subunit Gamma-2 antibodyAnti-Cell-Scattering Factor 140 Kda Subunit antibodyAnti-Csf 140 Kda Subunit antibodyAnti-Epiligrin Subunit Gamma antibodyAnti-Kalinin Subunit Gamma antibodyAnti-Kalinin/Nicein/Epiligrin 100 Kda Subunit antibodyAnti-Ladsin 140 Kda Subunit antibodyAnti-Laminin B2t Chain antibodyAnti-Laminin-5 Subunit Gamma antibodyAnti-Large Adhesive Scatter Factor 140 Kda Subunit antibodyAnti-Nicein Subunit Gamma antibodyAnti-LAMC2 antibodyAnti-LAMB2T antibodyAnti-LAMNB2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
