| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Lactadherin (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 40kDa band observed in lysates of cell line MCF7 (calculated MW of 43.1kDa according to NP_005919.2, and 37.5 according to NP_001108086.1 ). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
MFGE8 |
| Gene ID: |
4240 |
| Uniprot ID: |
MFGM_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_005919.2; NP_001108086.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_005919.2; NP_001108086.1). |
| Immunogen Sequence: |
KNNSIPDKQITAS |
| Post Translational Modifications | Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273. |
| Function | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Medin: Main constituent of aortic medial amyloid. |
| Protein Name | LactadherinBreast Epithelial Antigen Ba46HmfgMfgmMilk Fat Globule-Egf Factor 8Mfg-E8Sed1 Cleaved Into - Lactadherin Short Form - Medin |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-977225 |
| Cellular Localisation | MembranePeripheral Membrane ProteinSecretedCytoplasmic VesicleSecretory VesicleAcrosome MembraneLocated In The Acrosomal Region Of Zona-Pellucida Bound Sperm |
| Alternative Antibody Names | Anti-Lactadherin antibodyAnti-Breast Epithelial Antigen Ba46 antibodyAnti-Hmfg antibodyAnti-Mfgm antibodyAnti-Milk Fat Globule-Egf Factor 8 antibodyAnti-Mfg-E8 antibodyAnti-Sed1 Cleaved Into - Lactadherin Short Form - Medin antibodyAnti-MFGE8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/149786/346905/STJ16101070_1__46486.1681999088.jpg?c=1 "Anti-MFG-E8/Lactadherin/p47 antibody [MFG-06] (STJ16101070)")
