Anti-LACC1 antibody (4-54 aa) (STJ194579)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human LACC1 at the amino acid range 4-54
General Information
| Short Description | Rabbit polyclonal anti-Purine nucleoside phosphorylase LACC1 (4-54 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LACC1 |
| Gene ID | 144811 |
| Uniprot ID | LACC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human LACC1 at the amino acid range 4-54 |
| Immunogen Region | 4-54 aa |
| Specificity | This antibody detects endogenous levels of LACC1 at Human/Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity. Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages. Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface. The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity. Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance. Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR). Does not show laccase activity. |
| Protein Name | Purine Nucleoside Phosphorylase Lacc1Adenosine Deaminase Lacc1Fatty Acid Metabolism-Immunity NexusGuanosine Phosphorylase Lacc1Laccase Domain-Containing Protein 1S-Methyl-5'-Thioadenosine Phosphorylase Lacc1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusEndoplasmic ReticulumPeroxisomeUpon Stimulation Of The Pattern-Recognition Receptor (Prr) Nod2Localizes To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Purine Nucleoside Phosphorylase Lacc1 antibodyAnti-Adenosine Deaminase Lacc1 antibodyAnti-Fatty Acid Metabolism-Immunity Nexus antibodyAnti-Guanosine Phosphorylase Lacc1 antibodyAnti-Laccase Domain-Containing Protein 1 antibodyAnti-S-Methyl-5'-Thioadenosine Phosphorylase Lacc1 antibodyAnti-LACC1 antibodyAnti-C13orf31 antibodyAnti-FAMIN antibody |
Information sourced from Uniprot.org