Anti-KRT10 antibody (136-185 aa) (STJ92624)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Keratin 10 at the amino acid range 136-185
General Information
| Short Description | Rabbit polyclonal anti-Keratin, type I cytoskeletal 10 (136-185 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KRT10 |
| Gene ID | 3858 |
| Uniprot ID | K1C10_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Keratin 10 at the amino acid range 136-185 |
| Immunogen Region | 136-185 aa |
| Specificity | Cytokeratin 10 Polyclonal Antibody detects endogenous levels of Cytokeratin 10 protein. |
Additional Info
| Function | Plays a role in the establishment of the epidermal barrier on plantar skin. Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. |
| Protein Name | Keratin - Type I Cytoskeletal 10Cytokeratin-10Ck-10Keratin-10K10 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | SecretedExtracellular SpaceCell SurfaceCytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 10 antibodyAnti-Cytokeratin-10 antibodyAnti-Ck-10 antibodyAnti-Keratin-10 antibodyAnti-K10 antibodyAnti-KRT10 antibodyAnti-KPP antibody |
Information sourced from Uniprot.org