Anti-KPNA6 antibody (69-169 aa) [SRM5170] (STJ11107033)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal KPNA6 (69-169 aa) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5170 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:3000-1:20000IHC-P:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
Target Information
| Gene Symbol | KPNA6 |
| Gene ID | 23633 |
| Uniprot ID | IMA7_HUMAN |
| Immunogen Region | 69-169 aa |
| Immunogen Sequence | DSYVSSTTGESVITREMVEM LFSDDSDLQLATTQKFRKLL SKEPSPPIDEVINTPRVVDR FVEFLKRNENCTLQFEAAWA LTNIASGTSQQTKIVIEAGA V |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 69-169 of human KPNA6 (NP_036448.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Protein Name | Importin Subunit Alpha-7Karyopherin Subunit Alpha-6 |
| Database Links | Reactome: R-HSA-68616 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Importin Subunit Alpha-7 antibodyAnti-Karyopherin Subunit Alpha-6 antibodyAnti-KPNA6 antibodyAnti-IPOA7 antibody |
Information sourced from Uniprot.org