Anti-KMT2D antibody (1430-1510 aa) (STJ190998)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 1430-1510
General Information
| Short Description | Rabbit polyclonal anti-Histone-lysine N-methyltransferase 2D (1430-1510 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KMT2D |
| Gene ID | 8085 |
| Uniprot ID | KMT2D_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 1430-1510 |
| Immunogen Region | 1430-1510 aa |
| Specificity | MLL2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. |
| Protein Name | Histone-Lysine N-Methyltransferase 2dLysine N-Methyltransferase 2dAll1-Related ProteinMyeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 2 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3214841Reactome: R-HSA-3769402Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase 2d antibodyAnti-Lysine N-Methyltransferase 2d antibodyAnti-All1-Related Protein antibodyAnti-Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 2 antibodyAnti-KMT2D antibodyAnti-ALR antibodyAnti-MLL2 antibodyAnti-MLL4 antibody |
Information sourced from Uniprot.org