| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLKB1 |
| Gene ID: | 3818 |
| Uniprot ID: | KLKB1_HUMAN |
| Immunogen Region: | 391-500 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 391-500 of KLKB1 (NP_000883.2). |
| Immunogen Sequence: | IVGGTNSSWGEWPWQVSLQV KLTAQRHLCGGSLIGHQWVL TAAHCFDGLPLQDVWRIYSG ILNLSDITKDTPFSQIKEII IHQNYKVSEGNHDIALIKLQ APLNYTEFQK |
| Tissue Specificity | Found in plasma (at protein level). |
| Function | Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| Protein Name | Plasma Kallikrein Fletcher Factor Kininogenin Plasma Prekallikrein Pkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain |
| Database Links | Reactome: R-HSA-140837 Reactome: R-HSA-1592389 Reactome: R-HSA-9657688 Reactome: R-HSA-9657689 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasma Kallikrein antibody Anti-Fletcher Factor antibody Anti-Kininogenin antibody Anti-Plasma Prekallikrein antibody Anti-Pkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain antibody Anti-KLKB1 antibody Anti-KLK3 antibody |
Information sourced from Uniprot.org