| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KLK7 (30-253) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KLK7 |
| Gene ID: |
5650 |
| Uniprot ID: |
KLK7_HUMAN |
| Immunogen Region: |
30-253 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-253 of human KLK7 (NP_644806.1). |
| Immunogen Sequence: |
IIDGAPCARGSHPWQVALLS GNQLHCGGVLVNERWVLTAA HCKMNEYTVHLGSDTLGDRR AQRIKASKSFRHPGYSTQTH VNDLMLVKLNSQARLSSMVK KVRLPSRCEPPGTTCTVSGW GTTTSPDVTFPSDLMCVDVK LISPQDCTKVYKDLLENSML CAGIPDSKKNACNGDSGGPL VCRGTLQGLVSWGTFPCGQP NDPGVYTQVCKFTKWINDTM KKHR |
| Tissue Specificity | Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). |
| Function | May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. |
| Protein Name | Kallikrein-7Hk7Serine Protease 6Stratum Corneum Chymotryptic EnzymeHscce |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedIn Ovarian CarcinomaSecreted And Also Observed At The Apical Membrane And In Cytoplasm At The Invasive Front |
| Alternative Antibody Names | Anti-Kallikrein-7 antibodyAnti-Hk7 antibodyAnti-Serine Protease 6 antibodyAnti-Stratum Corneum Chymotryptic Enzyme antibodyAnti-Hscce antibodyAnti-KLK7 antibodyAnti-PRSS6 antibodyAnti-SCCE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
