| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Kelch-like protein 41 (268-318 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KLHL41 |
| Gene ID: |
10324 |
| Uniprot ID: |
KLH41_HUMAN |
| Immunogen Region: |
268-318 aa |
| Specificity: |
This antibody detects endogenous levels of KBTBA at Human/Rat |
| Immunogen: |
Synthesized peptide derived from the human KBTBA at the amino acid range 268-318 |
| Post Translational Modifications | Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. |
| Function | Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. |
| Protein Name | Kelch-Like Protein 41Kel-Like Protein 23Kelch Repeat And Btb Domain-Containing Protein 10Kelch-Related Protein 1Sarcosin |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPseudopodiumRuffleMyofibrilSarcomereM LineSarcoplasmic Reticulum MembraneEndoplasmic Reticulum MembranePredominantly Cytoplasmic But Can Colocalize With F-Actin At The Membrane Ruffle-Like Structures At The Tips Of Transformation-Specific Pseudopodia |
| Alternative Antibody Names | Anti-Kelch-Like Protein 41 antibodyAnti-Kel-Like Protein 23 antibodyAnti-Kelch Repeat And Btb Domain-Containing Protein 10 antibodyAnti-Kelch-Related Protein 1 antibodyAnti-Sarcosin antibodyAnti-KLHL41 antibodyAnti-KBTBD10 antibodyAnti-KRP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
