Anti-KLHL40 antibody (400-450 aa) (STJ194625)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human KBTB5 at the amino acid range 400-450
General Information
| Short Description | Rabbit polyclonal anti-Kelch-like protein 40 (400-450 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLHL40 |
| Gene ID | 131377 |
| Uniprot ID | KLH40_HUMAN |
| Immunogen | Synthesized peptide derived from the human KBTB5 at the amino acid range 400-450 |
| Immunogen Region | 400-450 aa |
| Specificity | This antibody detects endogenous levels of KBTB5 at Human/Mouse |
Additional Info
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex. Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination.the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear. |
| Protein Name | Kelch-Like Protein 40Kelch Repeat And Btb Domain-Containing Protein 5Sarcosynapsin |
| Database Links | |
| Cellular Localisation | CytoplasmMyofibrilSarcomereA BandI Band |
| Alternative Antibody Names | Anti-Kelch-Like Protein 40 antibodyAnti-Kelch Repeat And Btb Domain-Containing Protein 5 antibodyAnti-Sarcosynapsin antibodyAnti-KLHL40 antibodyAnti-KBTBD5 antibodyAnti-SRYP antibody |
Information sourced from Uniprot.org