| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLF10 |
| Gene ID: | 7071 |
| Uniprot ID: | KLF10_HUMAN |
| Immunogen Region: | 1-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human KLF10 (NP_001027453.1). |
| Immunogen Sequence: | MEERMEMISERPKESMYSWN KTAEKSDFEAVEALMSMSCS WKSDFKKYVENRPVTPVSDL SEEENLLPGTPDFHTIPAFC LTPPYSPSDFEPSQVSNLMA PAPSTVHFKSLSDTAKPHIA APFKEEEKSPVSAPKLPKAQ ATSVIRHTADAQLCNHQTCP MKAASILNYQNNSFRRRTHL NVEAARKNIPCAAVSPNRSK CERNTVADVDEKASAALYDF SVPSSETVICRSQPAPVSP |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. |
| Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock.binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. May play a role in the cell cycle regulation. |
| Protein Name | Krueppel-Like Factor 10 Egr-Alpha Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1 Tgfb-Inducible Early Growth Response Protein 1 Tieg-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 10 antibody Anti-Egr-Alpha antibody Anti-Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1 antibody Anti-Tgfb-Inducible Early Growth Response Protein 1 antibody Anti-Tieg-1 antibody Anti-KLF10 antibody Anti-TIEG antibody Anti-TIEG1 antibody |
Information sourced from Uniprot.org