| Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
| Post Translational Modifications | Phosphorylation probably regulates the interaction with NSH2. Phosphorylated at Tyr-605 and Tyr-606 by FYN, leading to GRB2 binding. N-glycosylated. |
| Function | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
| Protein Name | Kin Of Irre-Like Protein 1Kin Of Irregular Chiasm-Like Protein 1Nephrin-Like Protein 1 |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPredominantly Located At Podocyte Slit Diaphragm |
| Alternative Antibody Names | Anti-Kin Of Irre-Like Protein 1 antibodyAnti-Kin Of Irregular Chiasm-Like Protein 1 antibodyAnti-Nephrin-Like Protein 1 antibodyAnti-KIRREL1 antibodyAnti-KIRREL antibodyAnti-NEPH1 antibody |
Information sourced from Uniprot.org
