| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KIF7 (1044-1343) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIF7 |
| Gene ID: |
374654 |
| Uniprot ID: |
KIF7_HUMAN |
| Immunogen Region: |
1044-1343 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1044-1343 of human KIF7 (NP_940927.2). |
| Immunogen Sequence: |
QLDEAIEALDAAIEYKNEAI TCRQRVLRASASLLSQCEMN LMAKLSYLSSSETRALLCKY FDKVVTLREEQHQQQIAFSE LEMQLEEQQRLVYWLEVALE RQRLEMDRQLTLQQKEHEQN MQLLLQQSRDHLGEGLADSR RQYEARIQALEKELGRYMWI NQELKQKLGGVNAVGHSRGG EKRSLCSEGRQAPGNEDELH LAPELLWLSPLTEGAPRTRE ETRDLVHAPLPLTWKRSSL |
| Tissue Specificity | Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. |
| Post Translational Modifications | Polyubiquitinated by UBR3. |
| Function | Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation. Involved in the regulation of epidermal differentiation and chondrocyte development. |
| Protein Name | Kinesin-Like Protein Kif7 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5632684 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyLocalizes To The Cilium Tip |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif7 antibodyAnti-KIF7 antibodyAnti-UNQ340 antibodyAnti-PRO539 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
