| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Kinase D-interacting substrate of 220 kDa (1023-1073 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIDINS220 |
| Gene ID: |
57498 |
| Uniprot ID: |
KDIS_HUMAN |
| Immunogen Region: |
1023-1073 aa |
| Specificity: |
This antibody detects endogenous levels of KDIS at Human/Rat |
| Immunogen: |
Synthesized peptide derived from the human KDIS at the amino acid range 1023-1073 |
| Post Translational Modifications | Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF). |
| Function | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
| Protein Name | Kinase D-Interacting Substrate Of 220 KdaAnkyrin Repeat-Rich Membrane-Spanning Protein |
| Database Links | Reactome: R-HSA-170984Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinLate EndosomeLocalized At Late Endosome Before Or After Nerve Growth Factor (Ngf) Stimulation |
| Alternative Antibody Names | Anti-Kinase D-Interacting Substrate Of 220 Kda antibodyAnti-Ankyrin Repeat-Rich Membrane-Spanning Protein antibodyAnti-KIDINS220 antibodyAnti-ARMS antibodyAnti-KIAA1250 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
