| Post Translational Modifications | Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF). |
| Function | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
| Protein Name | Kinase D-Interacting Substrate Of 220 KdaAnkyrin Repeat-Rich Membrane-Spanning Protein |
| Database Links | Reactome: R-HSA-170984Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinLate EndosomeLocalized At Late Endosome Before Or After Nerve Growth Factor (Ngf) Stimulation |
| Alternative Antibody Names | Anti-Kinase D-Interacting Substrate Of 220 Kda antibodyAnti-Ankyrin Repeat-Rich Membrane-Spanning Protein antibodyAnti-KIDINS220 antibodyAnti-ARMS antibodyAnti-KIAA1250 antibody |
Information sourced from Uniprot.org
