| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WASHC5 |
| Gene ID: | 9897 |
| Uniprot ID: | WASC5_HUMAN |
| Immunogen Region: | 380-530 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-530 of human KIAA0196 (NP_055661.3). |
| Immunogen Sequence: | TADSACDPNNKRLRQIKDQI LTDSRYNPRILFQLLLDTAQ FEFILKEMFKQMLSEKQTKW EHYKKEGSERMTELADVFSG VKPLTRVEKNENLQAWFREI SKQILSLNYDDSTAAGRKTV QLIQALEEVQEFHQLESNLQ VCQFLADTRKF |
| Tissue Specificity | Expressed ubiquitously. |
| Function | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7. |
| Protein Name | Wash Complex Subunit 5StrumpellinWash Complex Subunit Strumpellin |
| Cellular Localisation | CytoplasmCytosolEndoplasmic ReticulumEarly EndosomeColocalizes With Syp/Synaptophysin In The External Molecular Layer Of The Dentate Gyrus And In Motoneurons Of The Ventral Horn Of Spinal Cord |
| Alternative Antibody Names | Anti-Wash Complex Subunit 5 antibodyAnti-Strumpellin antibodyAnti-Wash Complex Subunit Strumpellin antibodyAnti-WASHC5 antibodyAnti-KIAA0196 antibody |
Information sourced from Uniprot.org