Host: |
Mouse |
Applications: |
FC/WB/IF/IHC |
Reactivity: |
Cow/Dog/Human/Pig/Rabbit/Sheep |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Mouse monoclonal antibody anti-Keratin 8 is suitable for use in Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry research applications. |
Clonality: |
Monoclonal |
Clone ID: |
C-43 |
Conjugation: |
Unconjugated |
Isotype: |
IgG1k |
Formulation: |
PBS with 0.02% Sodium Azide. |
Purification: |
Affinity purified from tissue culture. |
Concentration: |
Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
Dilution Range: |
Flow Cytometry (1-2 µg/million cells in 0.1 ml, fix cells in 4% PFA for 10 min, at 4°C, permeabilize with 0, 2% saponin or digitonin for 15 min, at 4°C). Immunoblotting (1-2 µg/ml). Immunofluorescence (1-2 µg/ml). Immunohistology (formalin-fixed: 2-4 |
Storage Instruction: |
Store for up to 1 year at 2-8°C upon receipt. |
Gene Symbol: |
KRTAP10-8 |
Gene ID: |
386681 |
Uniprot ID: |
KR108_HUMAN |
Immunogen: |
A BALB/c mouse was immunized with a cytoskeleton preparation from HeLa cells. Fusion Partner: Sp2/0. |
Tissue Specificity | Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root.not detected in any other tissues. |
Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. |
Protein Name | Keratin-Associated Protein 10-8High Sulfur Keratin-Associated Protein 10.8Keratin-Associated Protein 10.8Keratin-Associated Protein 18-8Keratin-Associated Protein 18.8 |
Database Links | Reactome: R-HSA-6805567 |
Alternative Antibody Names | Anti-Keratin-Associated Protein 10-8 antibodyAnti-High Sulfur Keratin-Associated Protein 10.8 antibodyAnti-Keratin-Associated Protein 10.8 antibodyAnti-Keratin-Associated Protein 18-8 antibodyAnti-Keratin-Associated Protein 18.8 antibodyAnti-KRTAP10-8 antibodyAnti-KAP10.8 antibodyAnti-KAP18-8 antibodyAnti-KRTAP10.8 antibodyAnti-KRTAP18-8 antibodyAnti-KRTAP18.8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance