| Short Description : | Rabbit polyclonal KDM7A (417-735) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Kdm7a |
| Gene ID: | 338523 |
| Uniprot ID: | KDM7A_MOUSE |
| Immunogen Region: | 417-735 |
| Immunogen Sequence: | LKEDGFQPQSYLVQGVKALH TALKLWMKKELVSEHAFEIP DNVRPGHLIKELSKVIRAIE EENGKPVKSQGIPSVCPVSR PSNEASPPYHSRRKMRKLRD HNVRTPSNLDILELHTREVL KRLEMCPWEEDLLSSKLNGK FNKHLQPSSTVPEWRAKDND LRLLLTNGRIIKDERQLFAD RSLYTADSENEEDKKPTQNA NMKTEQSSGREEAESQGSPK PLNRIFTSVRSELRSRPSE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 417-735 of mouse KDM7A (NP_001028602.2). |
| Function | Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. |
| Protein Name | Lysine-Specific Demethylase 7aJmjc Domain-Containing Histone Demethylation Protein 1dLysine-Specific Demethylase 7Histone H3-Dimethyl-L-Lysine9 Demethylase 7a |
| Database Links | Reactome: R-MMU-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 7a antibodyAnti-Jmjc Domain-Containing Histone Demethylation Protein 1d antibodyAnti-Lysine-Specific Demethylase 7 antibodyAnti-Histone H3-Dimethyl-L-Lysine9 Demethylase 7a antibodyAnti-Kdm7a antibodyAnti-Jhdm1d antibodyAnti-Kdm7 antibodyAnti-Kiaa1718 antibody |
Information sourced from Uniprot.org
