Anti-Kdm6a antibody (550-700) (STJ110458)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KDM6A (550-700) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Kdm6a |
| Gene ID | 22289 |
| Uniprot ID | KDM6A_MOUSE |
| Immunogen Region | 550-700 |
| Immunogen Sequence | MPSVSQPGVHTACPRQTLAN GPFSAGHVPCSTSRTLGSTD TVLIGNNHVTGSGSNGNVPY LQRNAPTLPHNRTNLTSSTE EPWKNQLSNSTQGLHKGPSS HLAGPNGERPLSSTGPSQHL QAAGSGIQNQNGHPTLPSNS VTQGAALNHLS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 550-700 of mouse KDM6A (NP_033509.1). |
Additional Info
| Tissue Specificity | Expressed in brain, heart and spleen. |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. |
| Protein Name | Lysine-Specific Demethylase 6aHistone Demethylase UtxUbiquitously Transcribed Tpr Protein On The X ChromosomeUbiquitously Transcribed X Chromosome Tetratricopeptide Repeat ProteinHistone H3-Trimethyl-L-Lysine(27 Demethylase 6a |
| Database Links | Reactome: R-MMU-3214842Reactome: -MMU-9772755Reactome: -MMU-9818564 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6a antibodyAnti-Histone Demethylase Utx antibodyAnti-Ubiquitously Transcribed Tpr Protein On The X Chromosome antibodyAnti-Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6a antibodyAnti-Kdm6a antibodyAnti-Utx antibody |
Information sourced from Uniprot.org