Tissue Specificity | Expressed in brain, heart and spleen. |
Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. |
Protein Name | Lysine-Specific Demethylase 6aHistone Demethylase UtxUbiquitously Transcribed Tpr Protein On The X ChromosomeUbiquitously Transcribed X Chromosome Tetratricopeptide Repeat ProteinHistone H3-Trimethyl-L-Lysine(27 Demethylase 6a |
Database Links | Reactome: R-MMU-3214842Reactome: -MMU-9772755 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6a antibodyAnti-Histone Demethylase Utx antibodyAnti-Ubiquitously Transcribed Tpr Protein On The X Chromosome antibodyAnti-Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6a antibodyAnti-Kdm6a antibodyAnti-Utx antibody |
Information sourced from Uniprot.org