Name: Anti-KDM5C antibody [2E4-E1-G8] (STJ99023)
SKU: STJ99023
Availability: InStock

Anti-KDM5C antibody [2E4-E1-G8] (STJ99023)

SKU:

STJ99023

£144.00 - £348.00

Host:	Mouse
Applications:	WB/ICC
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Mouse monoclonal antibody anti-Lysine-specific demethylase 5C demethylase 5C is suitable for use in Western Blot and Immunocytochemistry research applications.

Clonality :	Monoclonal
Clone ID :	2E4-E1-G8
Conjugation:	Unconjugated
Isotype:	IgG2a
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000 ICC 1:150
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	KDM5C
Gene ID:	8242
Uniprot ID:	KDM5C_HUMAN
Specificity:	This antibody detects endogenous levels of KDM5C/Jarid1C/SMCX and does not corss-react with related proteins
Immunogen:	Purified recombinant human KDM5C/Jarid1C/SMCX protein fragments expressed in E.coli

Function	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Protein Name	Lysine-Specific Demethylase 5c Histone Demethylase Jarid1c Jumonji/Arid Domain-Containing Protein 1c Protein Smcx Protein Xe169 Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c
Database Links	Reactome: R-HSA-3214842
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Lysine-Specific Demethylase 5c antibody Anti-Histone Demethylase Jarid1c antibody Anti-Jumonji/Arid Domain-Containing Protein 1c antibody Anti-Protein Smcx antibody Anti-Protein Xe169 antibody Anti-Histone H3-Trimethyl-L-Lysine(4 Demethylase 5c antibody Anti-KDM5C antibody Anti-DXS1272E antibody Anti-JARID1C antibody Anti-SMCX antibody Anti-XE169 antibody

Information sourced from Uniprot.org

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Anti-KDM5C antibody [2E4-E1-G8] (STJ99023)