• Western blot analysis of extracts of Mouse brain, using (STJ28387) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-KDM4B antibody (1-1096) (STJ28387)

SKU:
STJ28387

£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KDM4B
Gene ID: 23030
Uniprot ID: KDM4B_HUMAN
Immunogen Region: 1-1096
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human KDM4B/JMJD2B (NP_055830.1).
Immunogen Sequence: MGSEDHGAQNPSCKIMTFRP TMEEFKDFNKYVAYIESQGA HRAGLAKIIPPKEWKPRQTY DDIDDVVIPAPIQQVVTGQS GLFTQYNIQKKAMTVGEYRR LANSEKYCTPRHQDFDDLER KYWKNLTFVSPIYGADISGS LYDDDVAQWNIGSLRTILDM VERECGTIIEGVNTPYLYFG MWKTTFAWHTEDMDLYSINY LHFGEPKSWYAIPPEHGKRL ERLAIGFFPGSSQGCDAFL
Function Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS).
Protein Name Lysine-Specific Demethylase 4b
Jmjc Domain-Containing Histone Demethylation Protein 3b
Jumonji Domain-Containing Protein 2b
Histone H3-Trimethyl-L-Lysine(9 Demethylase 4b
Database Links Reactome: R-HSA-3214842
Reactome: R-HSA-5693565
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Lysine-Specific Demethylase 4b antibody
Anti-Jmjc Domain-Containing Histone Demethylation Protein 3b antibody
Anti-Jumonji Domain-Containing Protein 2b antibody
Anti-Histone H3-Trimethyl-L-Lysine(9 Demethylase 4b antibody
Anti-KDM4B antibody
Anti-JHDM3B antibody
Anti-JMJD2B antibody
Anti-KIAA0876 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance