Anti-KCNK4 antibody (C-Term) (STJ13101280)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the c-terminal region of mouse KCNK4 (TRAAK) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat.
General Information
| Short Description | Rabbit polyclonal anti-KCNK4 (C-Term) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | KCNK4 |
| Gene ID | 50801 |
| Uniprot ID | KCNK4_HUMAN |
| Immunogen | A synthetic peptide from the c-terminal region of mouse KCNK4 (TRAAK) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat. |
| Immunogen Region | C-Term |
| Specificity | Specific for KCNK4. |
Additional Info
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses. Permeable to other monovalent cations such as Rb(+) and Cs(+). |
| Protein Name | Potassium Channel Subfamily K Member 4Twik-Related Arachidonic Acid-Stimulated Potassium Channel ProteinTraakTwo Pore Potassium Channel Kt4.1K2p4.1Two Pore K(+ Channel Kt4.1 |
| Database Links | Reactome: R-HSA-1299503Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonLocalizes At The Ranvier Nodes Of Myelinated Afferent Nerves |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 4 antibodyAnti-Twik-Related Arachidonic Acid-Stimulated Potassium Channel Protein antibodyAnti-Traak antibodyAnti-Two Pore Potassium Channel Kt4.1 antibodyAnti-K2p4.1 antibodyAnti-Two Pore K(+ Channel Kt4.1 antibodyAnti-KCNK4 antibodyAnti-TRAAK antibody |
Information sourced from Uniprot.org