| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Potassium channel subfamily K member 2 channel subunit (219-269 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNK2 |
| Gene ID: |
3776 |
| Uniprot ID: |
KCNK2_HUMAN |
| Immunogen Region: |
219-269 aa |
| Specificity: |
This antibody detects endogenous levels of KCNK2 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human KCNK2 at the amino acid range 219-269 |
| Post Translational Modifications | Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel. |
| Function | Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1. Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. |
| Protein Name | Potassium Channel Subfamily K Member 2Outward Rectifying Potassium Channel Protein Trek-1Trek-1 K(+ Channel SubunitTwo Pore Domain Potassium Channel Trek-1Two Pore Potassium Channel Tpkc1 |
| Database Links | Reactome: R-HSA-1299503Reactome: R-HSA-5576886 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Cell MembraneIsoform 4: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 2 antibodyAnti-Outward Rectifying Potassium Channel Protein Trek-1 antibodyAnti-Trek-1 K(+ Channel Subunit antibodyAnti-Two Pore Domain Potassium Channel Trek-1 antibodyAnti-Two Pore Potassium Channel Tpkc1 antibodyAnti-KCNK2 antibodyAnti-TREK antibodyAnti-TREK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
