Anti-KCNK10 antibody (16-66 aa) (STJ197368)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide derived from KCNK10 (TREK-2) at the amino acid range 16-66
General Information
| Short Description | Rabbit polyclonal anti-Potassium channel subfamily K member 10 channel subunit (16-66 aa) for use in WB, IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000IHC 1:100-200IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNK10 |
| Gene ID | 54207 |
| Uniprot ID | KCNKA_HUMAN |
| Immunogen | Synthetic peptide derived from KCNK10 (TREK-2) at the amino acid range 16-66 |
| Immunogen Region | 16-66 aa |
| Specificity | KCNK10 (TREK-2) protein (A237) detects endogenous levels of KCNK10 (TREK-2) |
Additional Info
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency. Permeable to other monovalent ions such as Rb(+) and Cs(+). |
| Protein Name | Potassium Channel Subfamily K Member 10Outward Rectifying Potassium Channel Protein Trek-2Trek-2 K(+ Channel Subunit |
| Database Links | Reactome: R-HSA-1299503Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 10 antibodyAnti-Outward Rectifying Potassium Channel Protein Trek-2 antibodyAnti-Trek-2 K(+ Channel Subunit antibodyAnti-KCNK10 antibodyAnti-TREK2 antibody |
Information sourced from Uniprot.org