Anti-KCNJ12 antibody (Cytoplasmic Domain) (STJ13100158)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the cytoplasmic domain of rat KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse.
General Information
| Short Description | Rabbit polyclonal anti-KCNJ12 (Cytoplasmic Domain) for use in IHC and WB in Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Kcnj12 |
| Gene ID | 16515 |
| Uniprot ID | KCJ12_MOUSE |
| Immunogen | A synthetic peptide from the cytoplasmic domain of rat KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse. |
| Immunogen Region | Cytoplasmic Domain |
| Specificity | Specific for KCNJ12. |
Additional Info
| Function | Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. It probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Protein Name | Atp-Sensitive Inward Rectifier Potassium Channel 12Inward Rectifier K(+ Channel Kir2.2Irk-2Potassium Channel - Inwardly Rectifying Subfamily J Member 12 |
| Database Links | Reactome: R-MMU-1296041Reactome: -MMU-1296053Reactome: -MMU-5576886Reactome: -MMU-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaT-Tubule |
| Alternative Antibody Names | Anti-Atp-Sensitive Inward Rectifier Potassium Channel 12 antibodyAnti-Inward Rectifier K(+ Channel Kir2.2 antibodyAnti-Irk-2 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 12 antibodyAnti-Kcnj12 antibodyAnti-Irk2 antibody |
Information sourced from Uniprot.org