• HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human KCNIP3 with C-terminal MYC tag probed with STJ72428 (1ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with STJ72428 (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.

Anti-KCNIP3 antibody (Internal) (STJ72428)

SKU:
STJ72428-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB-Trf
Reactivity: Human/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-KCNIP3 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-Recommended concentration, 1-3µg/ml
ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: KCNIP3
Gene ID: 30818
Uniprot ID: CSEN_HUMAN
Immunogen Region: Internal
Accession Number: NP_038462.1
Specificity: This antibody is expected to recognize isoform 1 (NP_038462.1) only.
Immunogen Sequence: HTPLSKKEGIK
Post Translational Modifications Palmitoylated. Palmitoylation enhances association with the plasma membrane. Proteolytically cleaved by caspase-3. Phosphorylation at Ser-63 inhibits cleavage by CASP3.
Function Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.
Protein Name Calsenilin
A-Type Potassium Channel Modulatory Protein 3
Dre-Antagonist Modulator
Dream
Kv Channel-Interacting Protein 3
Kchip3
Database Links Reactome: R-HSA-5576894
Reactome: R-HSA-9768777
Cellular Localisation Cytoplasm
Cell Membrane
Lipid-Anchor
Endoplasmic Reticulum
Golgi Apparatus
Nucleus
Also Membrane-Bound
Associated With The Plasma Membrane
In The Presence Of Psen2 Associated With The Endoplasmic Reticulum And Golgi
The Sumoylated Form Is Present Only In The Nucleus
Alternative Antibody Names Anti-Calsenilin antibody
Anti-A-Type Potassium Channel Modulatory Protein 3 antibody
Anti-Dre-Antagonist Modulator antibody
Anti-Dream antibody
Anti-Kv Channel-Interacting Protein 3 antibody
Anti-Kchip3 antibody
Anti-KCNIP3 antibody
Anti-CSEN antibody
Anti-DREAM antibody
Anti-KCHIP3 antibody

Information sourced from Uniprot.org

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