Anti-KCNIP2 antibody (1-90) (STJ29180)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KCNIP2 (1-90) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNIP2 |
| Gene ID | 30819 |
| Uniprot ID | KCIP2_HUMAN |
| Immunogen Region | 1-90 |
| Immunogen Sequence | MRGQGRKESLSDSRDLDGSY DQLTGHPPGPTKKALKQRFL KLLPCCGPQALPSVSENSVD DEFELSTVCHRPEGLEQLQE QTKFTRKELQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1). |
Additional Info
| Tissue Specificity | Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. |
| Post Translational Modifications | Palmitoylated. Palmitoylation enhances association with the plasma membrane. |
| Function | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart. |
| Protein Name | A-Type Potassium Channel Modulatory Protein Kcnip2Cardiac Voltage-Gated Potassium Channel Modulatory SubunitKv Channel-Interacting Protein 2Kchip2Potassium Channel-Interacting Protein 2 |
| Database Links | Reactome: R-HSA-5576894 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorDetected On Lipid RaftsIsoform 2: Cell MembraneIsoform 6: Cell Membrane |
| Alternative Antibody Names | Anti-A-Type Potassium Channel Modulatory Protein Kcnip2 antibodyAnti-Cardiac Voltage-Gated Potassium Channel Modulatory Subunit antibodyAnti-Kv Channel-Interacting Protein 2 antibodyAnti-Kchip2 antibodyAnti-Potassium Channel-Interacting Protein 2 antibodyAnti-KCNIP2 antibodyAnti-KCHIP2 antibody |
Information sourced from Uniprot.org