| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KCNIP2 (1-90) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNIP2 |
| Gene ID: |
30819 |
| Uniprot ID: |
KCIP2_HUMAN |
| Immunogen Region: |
1-90 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human KCNIP2 (NP_775284.1). |
| Immunogen Sequence: |
MRGQGRKESLSDSRDLDGSY DQLTGHPPGPTKKALKQRFL KLLPCCGPQALPSVSENSVD DEFELSTVCHRPEGLEQLQE QTKFTRKELQ |
| Tissue Specificity | Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. |
| Post Translational Modifications | Palmitoylated. Palmitoylation enhances association with the plasma membrane. |
| Function | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart. |
| Protein Name | Kv Channel-Interacting Protein 2Kchip2A-Type Potassium Channel Modulatory Protein 2Cardiac Voltage-Gated Potassium Channel Modulatory SubunitPotassium Channel-Interacting Protein 2 |
| Database Links | Reactome: R-HSA-5576894 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorDetected On Lipid RaftsIsoform 2: Cell MembraneIsoform 6: Cell Membrane |
| Alternative Antibody Names | Anti-Kv Channel-Interacting Protein 2 antibodyAnti-Kchip2 antibodyAnti-A-Type Potassium Channel Modulatory Protein 2 antibodyAnti-Cardiac Voltage-Gated Potassium Channel Modulatory Subunit antibodyAnti-Potassium Channel-Interacting Protein 2 antibodyAnti-KCNIP2 antibodyAnti-KCHIP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
