| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Potassium voltage-gated channel subfamily E member 1 (40-120 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNE1 |
| Gene ID: |
3753 |
| Uniprot ID: |
KCNE1_HUMAN |
| Immunogen Region: |
40-120 aa |
| Specificity: |
KCNE1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 40-120 |
| Post Translational Modifications | Phosphorylation inhibits the potassium current. N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5. |
| Function | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). |
| Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 1Delayed Rectifier Potassium Channel Subunit IskIks Producing Slow Voltage-Gated Potassium Channel Subunit Beta MinkMinimal Potassium Channel |
| Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinApical Cell MembraneMembrane RaftColocalizes With Kcnb1 At The Plasma MembraneTargets To The Membrane Raft When Associated With Kcnq1 |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 1 antibodyAnti-Delayed Rectifier Potassium Channel Subunit Isk antibodyAnti-Iks Producing Slow Voltage-Gated Potassium Channel Subunit Beta Mink antibodyAnti-Minimal Potassium Channel antibodyAnti-KCNE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
