| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome. Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation. Does not ubiquitinate proteins that are acetylated at the N-terminus. Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy. Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Kcmf1Fgf-Induced In Gastric CancerPotassium Channel Modulatory FactorPcmfZz-Type Zinc Finger-Containing Protein 1 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmLate EndosomeLysosome |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Kcmf1 antibodyAnti-Fgf-Induced In Gastric Cancer antibodyAnti-Potassium Channel Modulatory Factor antibodyAnti-Pcmf antibodyAnti-Zz-Type Zinc Finger-Containing Protein 1 antibodyAnti-KCMF1 antibodyAnti-FIGC antibodyAnti-ZZZ1 antibody |
Information sourced from Uniprot.org
