| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-KCC1/SLC12A4 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 150kDa band observed in Human Heart lysates (calculated MW of 121kDa according to NP_005063.1). Recommended concentration: 0.3-1µg/ml.IHC: Paraffin embedded Human Placenta. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SLC12A4 |
| Gene ID: | 6560 |
| Uniprot ID: | S12A4_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_005063.1 |
| Immunogen Sequence: | DPSHAPDNFRE |
| Post Translational Modifications | Phosphorylated, phosphorylation may regulate transporter activity. |
| Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia. Isoform 4: No transporter activity. |
| Protein Name | Solute Carrier Family 12 Member 4Electroneutral Potassium-Chloride Cotransporter 1Erythroid K-Cl Cotransporter 1Hkcc1 |
| Database Links | Reactome: R-HSA-426117 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 4 antibodyAnti-Electroneutral Potassium-Chloride Cotransporter 1 antibodyAnti-Erythroid K-Cl Cotransporter 1 antibodyAnti-Hkcc1 antibodyAnti-SLC12A4 antibodyAnti-KCC1 antibody |
Information sourced from Uniprot.org
