| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MYST1 (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KAT8 |
| Gene ID: |
84148 |
| Uniprot ID: |
KAT8_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KAT8/MYST1/MOF (NP_892003.2). |
| Immunogen Sequence: |
MAAQGAAAAVAAGTSGVAGE GEPGPGENAAAEGTAPSPGR VSPPTPARGEPEVTVEIGET YLCRRPDSTWHSAEVIQSRV NDQEGREEFYVHYVGFNRRL DEWVDKNRLALTKTVKDAVQ KNSEKYLSELAEQPERKITR NQKRKHDEINHVQKTYAEMD PTTAALEKEHEAITKVKYVD KIHIGNYEIDAWYFSPFPED |
| Post Translational Modifications | Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function. |
| Function | Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. |
| Protein Name | Histone Acetyltransferase Kat8Lysine Acetyltransferase 8Moz - Ybf2/Sas3 - Sas2 And Tip60 Protein 1Myst-1Hmof |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone Acetyltransferase Kat8 antibodyAnti-Lysine Acetyltransferase 8 antibodyAnti-Moz - Ybf2/Sas3 - Sas2 And Tip60 Protein 1 antibodyAnti-Myst-1 antibodyAnti-Hmof antibodyAnti-KAT8 antibodyAnti-MOF antibodyAnti-MYST1 antibodyAnti-PP7073 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and TDP2 knockout (KO) HeLa cells, using [KO Validated] TDP2 Rabbit polyclonal antibody (STJ119990) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98775/382823/STJ119990_1__79288.1713151323.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TDP2 knockout (KO) HeLa cells, using [KO Validated] TDP2 Rabbit polyclonal antibody (STJ119990) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")