Anti-KANK2 antibody (351-400 aa) (STJ93815)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KANK2 at the amino acid range 351-400
General Information
| Short Description | Rabbit polyclonal anti-KN motif and ankyrin repeat domain-containing protein 2 (351-400 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KANK2 |
| Gene ID | 25959 |
| Uniprot ID | KANK2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KANK2 at the amino acid range 351-400 |
| Immunogen Region | 351-400 aa |
| Specificity | KANK2 Polyclonal Antibody detects endogenous levels of KANK2 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by casein kinase II upon estrogen stimulation. Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription. |
| Function | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation. |
| Protein Name | Kn Motif And Ankyrin Repeat Domain-Containing Protein 2Ankyrin Repeat Domain-Containing Protein 25Matrix-Remodeling-Associated Protein 3Src-1-Interacting ProteinSipSrc-Interacting ProteinSrc1-Interacting Protein |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Kn Motif And Ankyrin Repeat Domain-Containing Protein 2 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 25 antibodyAnti-Matrix-Remodeling-Associated Protein 3 antibodyAnti-Src-1-Interacting Protein antibodyAnti-Sip antibodyAnti-Src-Interacting Protein antibodyAnti-Src1-Interacting Protein antibodyAnti-KANK2 antibodyAnti-ANKRD25 antibodyAnti-KIAA1518 antibodyAnti-MXRA3 antibodyAnti-SIP antibody |
Information sourced from Uniprot.org