| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | JUNB |
| Gene ID: | 3726 |
| Uniprot ID: | JUNB_HUMAN |
| Immunogen Region: | 1-240 |
| Immunogen Sequence: | MCTKMEQPFYHDDSYTATGY GRAPGGLSLHDYKLLKPSLA VNLADPYRSLKAPGARGPGP EGGGGGSYFSGQGSDTGASL KLASSELERLIVPNSNGVIT TTPTPPGQYFYPRGGGSGGG AGGAGGGVTEEQEGFADGFV KALDDLHKMNHVTPPNVSLG ATGGPPAGPGGVYAGPEPPP VYTNLSSYSPASASSGGAGA AVGTGSSYPTTTISYLPHAP PFAGGHPAQLGLGRGASTF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human JunB (NP_002220.1). |
| Post Translational Modifications | Ubiquitinated by ITCH, leading to its degradation. |
| Function | Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGAGCTCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity. |
| Protein Name | Transcription Factor JunbTranscription Factor Ap-1 Subunit Junb |
| Database Links | Reactome: R-HSA-2173796Reactome: R-HSA-6785807Reactome: R-HSA-9031628Reactome: R-HSA-9725371 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Junb antibodyAnti-Transcription Factor Ap-1 Subunit Junb antibodyAnti-JUNB antibody |
Information sourced from Uniprot.org
