Anti-JPH1 antibody (410-640) (STJ11100430)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal JPH1 (410-640) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JPH1 |
| Gene ID | 56704 |
| Uniprot ID | JPH1_HUMAN |
| Immunogen Region | 410-640 |
| Immunogen Sequence | RELSPDFYQPGPDYVKQRFQ EGVDAKENPEEKVPEKPPTP KESPHFYRKGTTPPRSPEAS PKHSHSPASSPKPLKKQNPS SGARLNQDKRSVADEQVTAI VNKPLMSKAPTKEAGAVVPQ SKYSGRHHIPNPSNGELHSQ YHGYYVKLNAPQHPPVDVED GDGSSQSSSALVHKPSANKW SPSKSVTKPVAKESKAEPKA KKSELAIPKNPASNDSCPAL EKEANSGPNSI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 410-640 of human JPH1 (NP_065698.1). |
Additional Info
| Tissue Specificity | Abundantly expressed in skeletal muscle. Very low levels in heart. |
| Function | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. |
| Protein Name | Junctophilin-1Jp-1Junctophilin Type 1 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinSarcoplasmic Reticulum MembraneLocalized Predominantly On The Plasma MembraneThe Transmembrane Domain Is Anchored In Endoplasmic/Sarcoplasmic Reticulum MembraneWhile The N-Terminal Part Associates With The Plasma MembraneIn Skeletal Muscle CellsIt Is Predominantly Localized At The Junction Of The A And I Bands |
| Alternative Antibody Names | Anti-Junctophilin-1 antibodyAnti-Jp-1 antibodyAnti-Junctophilin Type 1 antibodyAnti-JPH1 antibodyAnti-JP1 antibody |
Information sourced from Uniprot.org