• Western blot analysis of lysates from Mouse skeletal muscle, using JPH1 Rabbit polyclonal antibody (STJ11100430) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-JPH1 antibody (410-640) (STJ11100430)

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STJ11100430

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-JPH1 (410-640) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: JPH1
Gene ID: 56704
Uniprot ID: JPH1_HUMAN
Immunogen Region: 410-640
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 410-640 of human JPH1 (NP_065698.1).
Immunogen Sequence: RELSPDFYQPGPDYVKQRFQ EGVDAKENPEEKVPEKPPTP KESPHFYRKGTTPPRSPEAS PKHSHSPASSPKPLKKQNPS SGARLNQDKRSVADEQVTAI VNKPLMSKAPTKEAGAVVPQ SKYSGRHHIPNPSNGELHSQ YHGYYVKLNAPQHPPVDVED GDGSSQSSSALVHKPSANKW SPSKSVTKPVAKESKAEPKA KKSELAIPKNPASNDSCPAL EKEANSGPNSI
Tissue Specificity Abundantly expressed in skeletal muscle. Very low levels in heart.
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Protein Name Junctophilin-1
Jp-1
Junctophilin Type 1
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Single-Pass Type Iv Membrane Protein
Sarcoplasmic Reticulum Membrane
Localized Predominantly On The Plasma Membrane
The Transmembrane Domain Is Anchored In Endoplasmic/Sarcoplasmic Reticulum Membrane
While The N-Terminal Part Associates With The Plasma Membrane
In Skeletal Muscle Cells
It Is Predominantly Localized At The Junction Of The A And I Bands
Alternative Antibody Names Anti-Junctophilin-1 antibody
Anti-Jp-1 antibody
Anti-Junctophilin Type 1 antibody
Anti-JPH1 antibody
Anti-JP1 antibody

Information sourced from Uniprot.org

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