| Host: | Rabbit |
| Applications: | IHC/ELISA |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Inositol 1-4-5-Trisphosphate Receptor Type 2 is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification: | Affinity purification |
| Concentration: | 0.9 mg/mL |
| Dilution Range: | IHC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | ITPR2 |
| Gene ID: | 3709 |
| Uniprot ID: | ITPR2_HUMAN |
| Immunogen: | Synthetic peptide of human ITPR2 |
| Tissue Specificity | Isoform Short: Found in skeletal muscle and heart. |
| Post Translational Modifications | Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states.a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 Ip3 Receptor Isoform 2 Ip3r 2 Insp3r2 Inositol 1 -4 -5-Trisphosphate Receptor Type 2 Type 2 Inositol 1 -4 -5-Trisphosphate Receptor Type 2 Insp3 Receptor |
| Database Links | Reactome: R-HSA-112043 Reactome: R-HSA-114508 Reactome: R-HSA-139853 Reactome: R-HSA-1489509 Reactome: R-HSA-2029485 Reactome: R-HSA-2871809 Reactome: R-HSA-381676 Reactome: R-HSA-4086398 Reactome: R-HSA-422356 Reactome: R-HSA-5218921 Reactome: R-HSA-5578775 Reactome: R-HSA-5607763 Reactome: R-HSA-9664323 Reactome: R-HSA-983695 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Secretory Vesicle Membrane Forms Clusters On Endoplasmic Reticulum Membrane Upon Inositol 1 4 5-Trisphosphate Binding |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr2 antibody Anti-Ip3 Receptor Isoform 2 antibody Anti-Ip3r 2 antibody Anti-Insp3r2 antibody Anti-Inositol 1 -4 -5-Trisphosphate Receptor Type 2 antibody Anti-Type 2 Inositol 1 -4 -5-Trisphosphate Receptor antibody Anti-Type 2 Insp3 Receptor antibody Anti-ITPR2 antibody |
Information sourced from Uniprot.org