| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITGB8 |
| Gene ID: | 3696 |
| Uniprot ID: | ITB8_HUMAN |
| Immunogen Region: | 43-320 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-320 of human ITGB8 (NP_002205.1). |
| Immunogen Sequence: | EDNRCASSNAASCARCLALG PECGWCVQEDFISGGSRSER CDIVSNLISKGCSVDSIEYP SVHVIIPTENEINTQVTPGE VSIQLRPGAEANFMLKVHPL KKYPVDLYYLVDVSASMHNN IEKLNSVGNDLSRKMAFFSR DFRLGFGSYVDKTVSPYISI HPERIHNQCSDYNLDCMPPH GYIHVLSLTENITEFEKAVH RQKISGNIDTPEGGFDAMLQ AAVCESHIGWRKEAKRLLL |
| Tissue Specificity | Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells. |
| Function | Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis. |
| Protein Name | Integrin Beta-8 |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-216083Reactome: R-HSA-2173789 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Beta-8 antibodyAnti-ITGB8 antibody |
Information sourced from Uniprot.org