| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ITGA9 |
| Gene ID: | 3680 |
| Uniprot ID: | ITA9_HUMAN |
| Immunogen Region: | 30-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-250 of human ITGA9 (NP_002198.2). |
| Immunogen Sequence: | YNLDPQRPVHFQGPADSFFG YAVLEHFHDNTRWVLVGAPK ADSKYSPSVKSPGAVFKCRV HTNPDRRCTELDMARGKNRG TSCGKTCREDRDDEWMGVSL ARQPKADGRVLACAHRWKNI YYEADHILPHGFCYIIPSNL QAKGRTLIPCYEEYKKKYGE EHGSCQAGIAGFFTEELVVM GAPGSFYWAGTIKVLNLTDN TYLKLNDEVIMNRRYTYLGY A |
| Tissue Specificity | Expressed in vascular smooth muscle cells (at protein level). Expressed in the airway epithelium (at protein level). |
| Function | Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion. Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction. |
| Protein Name | Integrin Alpha-9Integrin Alpha-Rlc |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000178Reactome: R-HSA-445144 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-9 antibodyAnti-Integrin Alpha-Rlc antibodyAnti-ITGA9 antibody |
Information sourced from Uniprot.org