Anti-IRF5 antibody (380-460 aa) (STJ190152)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 380-460
General Information
| Short Description | Rabbit polyclonal anti-Interferon regulatory factor 5 (380-460 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IRF5 |
| Gene ID | 3663 |
| Uniprot ID | IRF5_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 380-460 |
| Immunogen Region | 380-460 aa |
| Specificity | IRF5 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection. |
| Protein Name | Interferon Regulatory Factor 5Irf-5 |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-909733Reactome: R-HSA-9860276 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm: Upon Activation By The Tlr Adapter Myd88 And Subsequent PhosphorylationTranslocates To The Nucleus |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 5 antibodyAnti-Irf-5 antibodyAnti-IRF5 antibody |
Information sourced from Uniprot.org