| Background | This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. |
| Tissue Specificity | Expressed predominantly in peripheral blood lymphocytes. |
| Function | Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. |
| Database Links | Reactome: R-HSA-166058 |
| Protein Name | Interleukin-1 Receptor-Associated Kinase 3Irak-3Il-1 Receptor-Associated Kinase MIrak-M |
| Alternative Names | Anti-Interleukin-1 Receptor-Associated Kinase 3 antibodyAnti-Irak-3 antibodyAnti-Il-1 Receptor-Associated Kinase M antibodyAnti-Irak-M antibodyAnti-IRAK3 antibody |
Information sourced from uniprot.org
