| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-INTS6 (1-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
INTS6 |
| Gene ID: |
26512 |
| Uniprot ID: |
INT6_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human INTS6 (NP_036273.1). |
| Immunogen Sequence: |
MPILLFLIDTSASMNQRSHL GTTYLDTAKGAVETFMKLRA RDPASRGDRYMLVTFEEPPY AIKAGWKENHATFMNELKNL QAEGLTTLGQSLRTAFDLLN LNRLVTGIDNYGQGRNPFFL EPAIIITITDGSKLTTTSGV QDELHLPLNSPLPGSELTKE PFRWDQRLFALVLRLPGTMS VESEQLTGVPLDDSAITPMC EVTGGRSYSVCSPRMLNQCL ESLVQKVQSGVVINFEKAG |
| Tissue Specificity | Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Function | Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role.an ectopic expression suppressing tumor cell growth. |
| Protein Name | Integrator Complex Subunit 6Int6Dbi-1Protein Ddx26Protein Deleted In Cancer 1Dice1 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Integrator Complex Subunit 6 antibodyAnti-Int6 antibodyAnti-Dbi-1 antibodyAnti-Protein Ddx26 antibodyAnti-Protein Deleted In Cancer 1 antibodyAnti-Dice1 antibodyAnti-INTS6 antibodyAnti-DBI1 antibodyAnti-DDX26 antibodyAnti-DDX26A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
