Western blot analysis of extracts of various cell lines, using INTS6 antibody (STJ28717) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-INTS6 antibody (1-280) (STJ28717)

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STJ28717
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: INTS6
Gene ID: 26512
Uniprot ID: INT6_HUMAN
Immunogen Region: 1-280
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human INTS6 (NP_036273.1).
Immunogen Sequence: MPILLFLIDTSASMNQRSHL GTTYLDTAKGAVETFMKLRA RDPASRGDRYMLVTFEEPPY AIKAGWKENHATFMNELKNL QAEGLTTLGQSLRTAFDLLN LNRLVTGIDNYGQGRNPFFL EPAIIITITDGSKLTTTSGV QDELHLPLNSPLPGSELTKE PFRWDQRLFALVLRLPGTMS VESEQLTGVPLDDSAITPMC EVTGGRSYSVCSPRMLNQCL ESLVQKVQSGVVINFEKAG
Tissue Specificity Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Function Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role.an ectopic expression suppressing tumor cell growth.
Protein Name Integrator Complex Subunit 6
Int6
Dbi-1
Protein Ddx26
Protein Deleted In Cancer 1
Dice1
Database Links Reactome: R-HSA-6807505
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Integrator Complex Subunit 6 antibody
Anti-Int6 antibody
Anti-Dbi-1 antibody
Anti-Protein Ddx26 antibody
Anti-Protein Deleted In Cancer 1 antibody
Anti-Dice1 antibody
Anti-INTS6 antibody
Anti-DBI1 antibody
Anti-DDX26 antibody
Anti-DDX26A antibody

Information sourced from Uniprot.org

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